Liverpool are investigating the trouble between away fans and local Seville police last night.
Scores of supporters were said to have been singled out by authorities in Seville.
And hundreds have complained of rough treatment by police in Spain following Liverpool's 3-3 draw with Sevilla on Tuesday.
Liverpool have now confirmed they will be investigating the trouble.
"Following detailed and troubling accounts given by Liverpool supporters attending the match against Sevilla last night, the club is seeking to establish the facts regarding their treatment at the hands of the host stewards and local police force," read the statement.
"The safety and security of our supporters is our paramount concern and we intend to gather all the relevant information before responding further."