Rodolfo Borrell's youngsters have been in impressive form in the competition so far but must first overcome a tricky encounter at home to Southend United if they are to secure a place in what could be the match of the round.
The draw in full:
Liverpool or Southend v Manchester United or Newcastle United
Leeds United or Aston Villa v Middlesbrough
Leicester City or Preston North End v Sheffield United
Chelsea or Barnsley v Fulham or Watford