The Spaniard has fired seven goals this season but so far in his Chelsea career has failed to recreate the form which at one time made him a Kop favourite.
"Now he is playing for Chelsea and if I play I will be marking him," Skrtel told Liverpoolfc.com.
"It's going to be special but we have to look after him because even if he isn't scoring goals at the moment he is still one of the best strikers in the world and still dangerous.
"We have to keep our eye on him for 90 minutes and not let him score.
"I haven't seen Chelsea play too many times this season but from what I've heard his performances are better than last season.
"It's going to be hard playing against him but I believe in my qualities and the quality of our team and I believe we won't let him score."