Liverpool were beaten 2-1 by City on Boxing Day but the Slovakian centre-back is confident the Reds can exact revenge.
"Things are going well but there is still a long way to go," Skrtel told the Liverpool Echo.
"We can't look too far ahead. We need to keep going game to game and now our focus is on getting three points against Manchester City.
"We will look forward to that challenge. We know the atmosphere created by our fans will be amazing."
For breaking stories and all the great banter like us on Facebook: facebook.com/tribalfootball