Liverpool coach Mauricio Pellegrino rates their clash with Manchester United as the biggest game in the world.
"Every derby is different but Manchester United versus Liverpool is the most important derby in the world," he told the club's official website.
"A lot of people in South America talk about this game, and it's the same in Europe and Asia.
"I was lucky enough to play in a Real Madrid versus Barcelona derby and then in a Liverpool versus Manchester game. These were wonderful opportunities for me.
"If I was at home in Argentina, I would be watching this game."
Liverpool will be boosted by the absence of Cristiano Ronaldo in the game, but Pellegrino believes his compatriot Carlos Tevez will be a big threat.
"Cristiano is an important player, but it won't make a massive difference to them because they have a lot of good players," he added.
"Carlos is a good player. He is very strong and a fighter. He fights until the end of every game."