Reina will serve a three-match ban following his red card, bringing to an end his ever-present record under Dalglish.
Either Alexander Doni or Brad Jones will fill in.
"Doni is experienced, obviously coming from Italian football," he told liverpoolfc.tv.
"He's worked really hard and he's got a lot sharper since he got here with the work he's put in. He's a credit to himself. He looks after himself and comes in every day and works really hard.
"To play the game against Villa would be the next step.
"It's unfortunate circumstances for Pepe but now someone else can step in, either Doni or Brad."