Victory over Trabzonspor would put the Ligue 1 side through as Group B runners-up at the expense of the Turkish visitors.
"I think it's a very important game for the club to show its' progress by playing in the Champions League," he told French TV programme Telefoot.
"I think we were not very lucky at the start of competition. People doubted us but we have the opportunity to change course and to qualify, which would be a great achievement for Lille.
"Everyone wants to ensure that happens and we are very motivated by this challenge."