The Glasgow giants host the Russians in the final group fixture of Europe's premier club competition and manager Lennon is well aware that they must come away with maximum points if they are any chance of progressing to the Round of 16.
"We have got to go for it," he said.
"This is their moment and they might not get this opportunity again. I'm not going to put any pressure on them - I just want them to go and play as they can at home on a big European night.
"By that I mean play aggressively and with a good tempo to the game.
"We have players who can score goals, and have flair players who can rise to the occasion. They are capable of doing it. Spartak are a dangerous team, but they have not got the calibre of Barcelona or the structure of Benfica in the way they play.
"But they do have a lot of flair in their team as well so we have to be aware of that."