The United academy graduate has not been back to his old stomping ground since he left to join Hannover 96.
"I'm really looking forward to it," says Zieler, who has been impressive in his last two games for Claudio Ranieri's side, in place of the concussed Kasper Schmeichel.
"I know Old Trafford very well. It is great to go back and maybe play there. Hopefully, we can continue like we did in the last league game (against Burnley).
"I still know a few of the staff and one or two players I played with, so it will be good to see them.
"I met them at the Community Shield, so I caught up with them there, so it will be nice to see them again."