Liverpool boss Jurgen Klopp insists their relationship with Southampton has been mutually beneficial.
Virgil van Dijk, a January target for the Reds, battled to keep the hosts' attack at bay during yesterday's 3-0 reverse.
Saints have previously sold Adam Lallana, Dejan Lovren, Sadio Mane, Nathaniel Clyne and Rickie Lambert to Liverpool in recent years.
"There is a special relationship between Southampton and Liverpool," argued Klopp going into the game.
"We've given them a lot of money for a few players. It was always a fair deal - it looks like they suffered in different moments - but Liverpool always paid really well for the players."