The Merseyside club drew 1-1 with Kazan in what was Klopp's first match at Anfield a fortnight ago.
However, the German manager is hopeful is side can improve on that result and climb up the rankings in Europa League Group B.
"It's not always the biggest advantage to play 11 against 10 and Rubin Kazan did well on that evening, of course," Klopp said.
"As I remember, we had our chances and the best moments from Kazan were for sure in the first half when they were 11 against 11.
"It's not a problem, it's football. We know that it's pretty hard tomorrow so that's why we are here, that's why for us the Europa League is a very, very big challenge because all of these teams in this tournament have their targets.
"But we have our targets and that's the only thing I'm interested in."