The Latics have found it difficult to play flowing football at the JJB Stadium this year on what boss Steve Bruce admits is the worst pitch in the league.
"Arsenal pass the ball brilliantly, but goodness knows how they will cope on our pitch," he told the Wigan Evening Post.
"Hopefully it will play into our hands, but Arsenal do have world-class players throughout who can probably play on any surface.
"It's going to be a very tough game and, if we can take anything out of it, that would be a big bonus for us.
"We've got home advantage and we'll give it a right good go."
Kirkland is confident that Bruce will be happy with the team whatever the result as long as the players put the effort in.
"The gaffer has always told us if we put maximum effort in and end up getting beaten by good football, so be it.
"He just asks us to give everything we have got on the pitch, play your best, and see what happens.
"We are now playing the way the gaffer wants us to. We've tuned into his ideas, and hopefully that will see us getting out of relegation trouble."