Matuidi accepts they go into the second-leg of their Champions League tie at Tottenham as underdogs.
As the first leg ended 2-2 in Turin, they must either win or play a score draw of 2-2 and above.
“Wembley is a wonderful stadium, I had the fortune of playing there with the France team," Matuidi told Sky Sport Italia.
“It won't be easy on Wednesday, as Tottenham are a team who play good football, are on form domestically and did great things in the Champions League, including the first leg against us.
“In any case, we proved in Turin that we can cause them serious problems, so we are going to London looking to win and score goals. If we play the way we know how, the way we did against Lazio, then it's possible."