Juve go to Fulham tonight defending a 3-1 lead from the first-leg of their Europa League tie.
Zaccheroni will have to choose between goalkeepers Antonio Chimenti and Pinsoglio as he is also without Gianluigi Buffon and Alex Manninger.
Zaccheroni admits he will be taking a massive gamble if he elects to hand 20-year-old Pinsoglio his debut tonight.
"You know him better than I do," said Zaccheroni. "I have never seen him playing in Serie A and I have never seen him in the youth team.
"All I have seen of him has been in training but from what I have seen of him he will have a bright future."