Wayne Rooney proved the matchwinner on Saturday.
But Jol said: "Rooney causes you problems because he’s playing behind your midfield in that hole and he’s very clever but Van Persie is the main man.
"He’s the one who sets them up with the little flicks and combinations. He will be the top scorer in the Premier League again, as he was last year. He scores a lot of goals.
"Van Persie is like Zlatan Ibrahimovic. Wherever Zlatan goes, they will be champions. I think Van Persie has that quality as well. If the rest are useless, he will not win you the title. But United are very good — plus they’ve got Van Persie."