Jewell sees no reason why Latics cannot continue their love affair with the competition.
"You can't predict with Wigan," Jewell, speaking in Wigan at the Beko Keepy-Uppy Challenge, said.
"I'm sure Uwe will be saying we've got to be careful with the wounded animal because they've had a bit of stick in the press. But I look at the way Wigan have played this season and they're aggressive in their style of play, their movement is good and I think they have a chance.
"They're second favourites but Wigan have made complete nonsense of people betting on favourites with Manchester City in the final, Everton in the quarter-finals (last season), Manchester City this year. Who's to say they can't get another one against Arsenal on Saturday? It's going to be tough but they'll go there with absolutely no pressure."
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