Japan give Man Utd signing Kagawa all-clear to miss Olympics
Twenty-three-year-old Kagawa is eligible to compete but it has been confirmed the midfielder, who will join United from German champions Borussia Dortmund once he has passed a medical and gained a work permit, will not be selected.
Japanese FA technical director Hiromi Hara said: "Kagawa is one of the leading members of the Japan national senior team and he is almost certainly going to join one of the biggest clubs in the world.
"We came to the conclusion that not giving him enough rest is not good for his future nor our final World Cup qualifiers.
"I talked to Kagawa directly and told him he would not be chosen."