The England international has sustained a broken bone in his foot and is likely to spend up to six weeks on the sidelines which will end his successive match streak of 51 in the Premier League.
Jagielka is well aware that Baines is one of the Toffees key players and has his fingers crossed that somebody can step in and pick up where he left off.
"Bainesy has probably missed three or four games with a slight hamstring strain over the last five years and the left-back slot has always been done blindfolded when the manager has come to write the team-sheet," he said.
"When someone does get injured and you are going to miss him from between one and six weeks there is going to be a little bit of to-ing and fro-ing with who is going to play.
"We've been fortunate that we have not had to do that so far, so we will look at the positives in that respect and deal with what's to come.
"I'm sure the manager will enjoy the challenge of coming up with the right personnel and formation to play against Stoke to come away with the three points.
"Bryan Oviedo wasn't in the squad (last weekend) but he will obviously be an option.
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