"I want to leave the club. I said that before, and the arrival of Mark Hughes will make no difference," said Isaksson.
"I will not be fighting for my place or talking to the new manager about changing my mind."
Isaksson told Reuters he was a free agent but City said on Thursday he had one year left on the contract he signed in 2006.
Asked about Hughes's appointment, Isaksson said: "I don't really care. Hopefully, I won't be at the club next season."
Media reports in Sweden and England have linked Isaksson with a move to Premier League Fulham but he said he had not spoken to any clubs and was focusing strictly on Euro 2008.