The Dutchman was a key factor for the Nerazzurri's triumph in the Champions League last term and ahead of the 2010/11 group stage opener against FC Twente, is keen for more success.
"Inter can retain the Champions League title, for many reasons, but it will obviously not be easy," he said.
"We have the advantage that our squad has not changed a lot, some new players have arrived bringing new qualities. It will be important to begin in good form.
"Twente have a good squad and I'm sure they will try to put us in difficulty. However, we clearly want to make the best of our qualities in order to start our campaign with a win."