"To replace a world class player like Ibrahimovic, another great goal scorer will arrive in the form of Eto'o," captain Zanetti told Argentine newspaper La Nacion.
"He'll form a perfect partnership with Milito. They will get on like a house on fire."
Some suggest selling their Capocannoniere will weaken Inter, but Zanetti has other ideas.
"Our intention is to be at the top at international level as well as in Italy. We are putting together a very strong side, on a par with the best in Europe.
"Of course it won't be easy to challenge for the Champions League, because all the contenders are gaining strength, but we are doing very well and I am confident."