Both players have been linked with moves away this summer.
"You all know how important Samir is for us, because he did so well replacing Julio Cesar. He is a charismatic figure and as far as I am concerned Inter cannot do without Handanovic in the future," said Strama.
"Guarin was also in the papers, but I see no chance of either of them leaving Inter. We are keeping a tight grip on our players."