The two teams will meet in the opening game of the new season.
“I think the start of the league season always hides many pitfalls," Spalletti warned on Inter TV.
“No-one has ever shown that your first result conditions your season, there are many things to put in place, but we do have to win the first one.
“Not least to cause problems for the Sassuolo President, who said he has no more room on his wall for pictures of wins over Inter.
“He's already got a lot, so we need to try and take away the chance for any more…"