Spurs have progressed through to the Round of 16 by beating Lyon 3-2 on aggregate thanks to Mousa Dembele's 90th minute leveller in tonight's 1-1 draw and Villas-Boas cannot wait to meet Andrea Stramaccioni's Nerazzurri in the next stage after they dismantled CFR Cluj 5-0 over the two legs.
Spurs and Inter met in the Champions League two seasons ago and Villas-Boas is hoping the next two fixtures can live up to the hype.
"We had two magnificent games against Inter and we just want to recreate a special night that everyone remembers at the club," he said.
"Going through against Inter Milan and Lyon puts you in a good place to win the competition."
On those fateful nights back in the 2010/11 season, Gareth Bale scored a second-half hat-trick as Spurs lost 4-3 at the San Siro before the North London club managed a 3-1 victory at White Hart Lane as they topped Group A before losing to Real Madrid in the quarter-finals.
Inter also fell at that stage, losing to German club Schalke 7-3 on aggregate.