Manchester United could be without up to seven key players ahead of the Premier League's return this weekend.
Jose Mourinho is experiencing a player shortage in the lead-up to Saturday's clash with West Bromwich Albion at Old Trafford.
Star striker Zlatan Ibrahimovic and influential midfielder Ander Herrera are both sidelined through suspension but there are a handful of senior players who may miss with injury.
Captain Wayne Rooney was already suffering with a knee problem which saw him omitted from the England squad and remains in doubt at club level.
Midfielder Paul Pogba was left out of the France squad after sustaining a hamstring injury against Middlesbrough and is also expected to miss the visit of the Baggies.
And the international 'break' has not been kind to the Red Devils with a further trio of players injured on international duty.
Chris Smalling and Phil Jones collided at England training last week prompting both players to be withdrawn from Southgate's playing group.
Jones has a suspected broken toe while Smalling was seen in a knee brace on Monday night and there are fears he may miss most of April, in which United have no less than nine fixtures.
To add to that, Marouane Fellaini will miss Belgium's friendly with Russia on Tuesday because of a 'toe complaint' so must be under a cloud for the weekend.
Clarification on the extent of the injuries is likely to be made by Mourinho at Friday's pre-match press conference.