19-year old Wilshere has endured an injury-plagued start to the season, possibly from too much of a heavy workload late last term, and Wenger says he will avoid doing the same with Wales skipper Ramsey who scored the winner at Marseille in the Champions League last night.
"It was a great finish, you see Ramsey in front of goal and you know you have a good chance to score. He is a goalscorer," Wenger told the club's official website.
"I do not want to overplay him. I have seen in my mind that he had been injured for a year. Wilshere played a lot last year [and is now injured].
"I try to be a bit more cautious when I can."
The late Ramsey goal gave the Gunners a 1-0 win at the Stade Velodrome, enabling them to go to the top of Group F and Wenger feels the team is finally getting back to somewhere near its best.
"It will help us but if you look back last five or six games you will see we only have one defeat," Wenger continued. "We are slowly getting there - that will help tonight.
"We've made a little step forward but we have to be humble. We are a team who must continue to grow and we have to show that. The next game at home against Marseille is very important."