The Scottish champions beat the Spanish title holders 2-1 at Celtic Park in the group stage of Europe's premier club competition last season and the boss suggests he is again gunning for the might of the Blaugrana this time around.
"Most people will think we can't do it, that lightning won't strike twice," he said.
"But I have to believe we can get something out of the game. We'll be in front of our own fans and that will be good for my players. Barca have international players who have played at every level all over the world.
"They have been in hostile environments so having 60,000 people shouting at them will not affect them. But I hope it will inspire our team to go out and do it again.
"I was pleased with the performance in Milan (2-0 loss a fortnight ago). They were not fazed at all. But Barca are a different animal, home or away.
"They are the class team in this group by a considerable margin. I will try and be compact again. I have a little bit more legs in the team than I did last year.
"I have lost (Victor) Wanyama and (Gary) Hooper but with Van Dijk and Brown being fit this time - and I hope James Forrest will be back - that will give us something extra in terms of pace in wide areas."
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