Jakupovic was in his second loan spell, but has returned to the Tigers following the injury and suspension to City first choice keeper Allan McGregor.
He told Leyton Orient's website: "I would like to take this opportunity to thank everyone for their support.
"It has been an honour and pleasure playing for Leyton Orient.
"I wish for the team the best of luck for the future. Players and fans...you guys are great!!!"
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