Stoke host United looking to build on an impressive display in Manchester at the end of October when they twice took the lead and came very close to producing another upset.
"We did okay at Old Trafford and were 12 minutes away from beating them and on the day we did exceptionally well, especially in the attacking third," said Hughes.
"We didn't quite see the game out but hopefully we will this time.
"You want to test yourself against the best teams in the Premier League and best teams in Europe and that is what United are.
"The chance for us is to make sure our level is good and we can give them a game.
"We set the standard last time out at home (beating Chelsea 3-2) and if we can reach that United will know they have been in a game.
"They (United) got back on track against Villa at the weekend but it does depend who we have to face.
"Players unavailable include Robin van Persie, who gives them a different kind of threat, but they still have outstanding players who can make an impact.
"But we are playing well, creating chances and we can score against anyone."