Hughes will have to do without a number of key defenders against Spurs, with Anton Ferdinand, Fabio, Armand Traore and Stephane Mbia all unavailable through injury.
"We have got a number of injuries at the back, unfortunately," the QPR manager said. "Anton is not going to be available, although [his hamstring injury] is actually settling down a little bit quicker than we thought initially.
"That is good news but he is not going to be available this weekend and Fabio is going to be out for a number of weeks, which is a blow.
"To compound that, Armand Traore is not available either because of injury so we're going to have to move people around to compensate for that."