Holtby believes they can assert their Champions League credentials by beating Jose Mourinho's men at White Hart Lane.
"Tottenham are going places," said Holtby.
"It's a massive game, for the fans as well. We are playing at the Lane against Chelsea and if we can win that game we can make it a special weekend.
"We are aiming high. We want to get in the top four and we want to play Champions League.
"I think we have the squad to do that, the quality and depth as well.
"It is very important to win a big game like Chelsea to stay up top and give us the confidence we need for the rest of the season.
"Everyone is up for it, I'm up for it, and I can't wait for the next game."