The German club host the Gunners tomorrow night following their win at the Emirates a fortnight ago and midfielder Holtby is of the belief that he and his teammates can again do the job.
"I think that Arsenal are a little bit resentful about us stealing three points on their home territory. But we are wary and well-prepared," he told the club's official website.
"We only concentrate on tomorrow. The form of the day could be a deciding factor, one mistake can immediately be punished.
"It will be a very good game I think," he continued.
"The thing [Veltins-Arena] will be sold-out and at the moment we are still table-toppers [in Group B], so we have to light the fire from the beginning and show [Arsenal] that we are the landlords. Then we will see the result."