Holloway is fuming at claims United could field an under-strength team and Blackpool avoid relegation by becoming the first team this season to win at Old Trafford.
"They will be relieved if we lose and get relegated," said Holloway.
"Then I am not badgering them.
"I am so annoyed. Sir Alex Ferguson is a winner. He would never dream of not being interested in winning any match.
"That man deserves to pick whatever team he wants to pick. No one should question it.
"Look at his record. Those people running the game, what planet are they on? They must have beamed down from planet Zarf. They are not in the right world.
"They think we can only beat Manchester United if they are weak. What a load of baloney. Unfortunately, that is what we are dealing with."
Holloway added: "Already, they are saying Blackpool can't beat them. I am glad I don't go to work thinking that, otherwise I would never have got promoted last year.
"I would have been relegated from the Championship because that is what everyone said was going to happen.
"That attitude offends me. It upsets me on a personal note about my club and definitely on a Manchester United note. How dare they talk about Sir Alex like that? Haven't they seen his hairdryer? Haven't they seen how successful he is.
"On Sunday, we have to try and do the impossible. It's got to be perfect. No one else has beaten them. And if we do, they might get fined because we are rubbish."