The former Arsenal striker netted after 17, 24 and 48 minutes to end his Primera Liga goal drought and set Barcelona on the road to a comprehensive victory which sees them move provisionally top of the Primera Liga.
Lionel Messi added a fourth goal for the Catalans and Emilio Viqueira scored a late penalty for the home side.
Barcelona inspired by a brilliant and long-overdue performance from Henry, now go top and continue to shine.