"We will definitely remember that they beat us in the last one," Hargreaves told the Manchester Evening News. "We played very well and were just unfortunate not to win the game.
"I still don't know how we didn't win. We will remember that and go into the game with confidence."
And, in the week Manchester commemorated the 50th anniversary of the Munich air crash, Hargreaves says the disaster will be a similar source of motivation to succeed.
"The most important thing is the Munich crash and I think everybody will have that at the front of their thoughts. It will be an emotional day and very special to be a part of," he said.
"Whether I get to play is not down to me. I don't get paid to make those decisions, just to play and that's what I'll do."