Guzan said it is important for the players, staff and supporters to stick together in a bid to end the recent run of defeats.
He believes the team can draw inspiration from some of their early-season displays.
"There is no doubt in my mind we'll have a response," the keeper told Villa's website.
"Yes we are going through a bad run of result but it doesn't make us a bad team.
"We are still the same team that won away at the Emirates and have picked up other positive results along the way so we'll dust ourselves off and go again and find a way to get a win on Saturday."