The 24-year old sustained a groin injury in the weekend's 3-0 loss to Chelsea with manager Alan Pardew confirming it would at least four weeks on the sidelines and as many as six.
"Danny Guthrie could be a four-to-six-week job and there's no Cheik (Tiote) this weekend so we really are up against it squad wise and it's important now that everybody plays their part," he said ahead of the weekend's trip to Norwich City.
Pardew now has to deal with a host of injuries to key players as central defender Steven Taylor is out for the season with an Achilles problem and captain Fabricio Coloccini has a thigh injury but could be ok for the weekend.
"I think there's an outside chance he could play but we won't play him and put him at risk. His injury looks a lot better than we thought so that is the positive news that we got coming out of the treatment room this week," he added.