The 31-year old striker has departed the A-League to sign with Chinese outfit Beijing Baxi after returning to Newcastle in 2011.
Griffiths originally departed the Hunter to join Romanian club National Bucharest back in 2004 and has since had spells with Rapid Bucharest and Chinese clubs Liaoning and Beijing Guoan - the latter with whom he helped win the 2009 Chinese Super League championship.
"This was a hard decision because I love this Club and town but I needed to consider my young family and do what is best for them, and right now that is going to play in China," Griffiths said.
"I will always appreciate the management of the Jets for supporting me at this point in my career.
"One of the great things about the Club is that at any time you can sit down, talk about your problems or opportunities and they will discuss it and attempt to come up with the best scenario or outcome for all concerned."