Robbie Keane and Tom Huddlestone both grabbed two goals against Fulham before substitute Jermain Defoe wrapped up the scoring. Clint Dempsey had given the visitors brief hope with a strike on the hour mark.
Despite the attacking power Spurs showed, it was Ledley King's first appearance of the season that gave the home fans the biggest cheer.
King has endured a wretched 18 months with injury. It was a year ago that he picked up a foot problem and he has undergone knee surgery since.
"He's still getting better," said Ramos. "He's not 100% yet but we needed him to play today because we did not have enough defensive players.
"His performance was good overall and it's obvious he has experience which he has brought to the team. It is good to have him back on the pitch.
"To have a players like Ledley in defence is great because of the international experience he brings and he knows the team very well. Physically he needs to adapt to the rhythm of the matches.
"Tomorrow we will have a look at him and how his knee is getting on. It depends on how he comes out of this game as to whether he can play again during the week."
Fulham had Moritz Volz dismissed for two yellow cards, and caretaker boss Ray Lewington feels his side lacked a physical edge.
"If they play like that they will get relegated but I hope they won't," said Lewington. "Everything that could go wrong went wrong today.
"We are realistic to know that the performance was good either. We've got to put it right."