Giggs told BBC One: "Obviously as a former team-mate and a friend of David I am disappointed for him, but he will take it on the chin and carry on his career.
"It's one of those things, it was not meant to be.
"That's Stuart Pearce's job to pick a team that he thinks will win and that's what he's done. Unfortunately David is not in that 18.
"I would like to say as a friend I wish he was. But I am sure the lads who are picked will go out and do the best they can."