The visitors will take encouragement from last season's recovery from 3-0 down to draw 3-3 - and their 2011 Champions League semi-final win - but the London side, energised by Roberto Di Matteo's summer changes, look in prime form.
Veteran midfielder Giggs said: "Sometimes new players settle in straight away and that seems to be the case at Chelsea.
"They've got off to a great start this season, particularly in the league. We're going to have to play well if we're going to get a result.
"I don't know why we've found it so tough (there). In the 1990s we used to go there and win quite regularly.
"Obviously when Jose Mourinho came and they won the league it was always a tough place to go.
"I'm really not sure why it's been so tough for us. Last year we can take heart from how well we played and I think we probably deserved to win.
"We came back from three goals down and managed to draw 3-3. Also, in the Champions League a couple of years ago, we played well and won.
"I think we've shown good form there in the last few years but just haven't got the results we've wanted."