The pint-sized Italian international believes a big upset could be on the cards.
Giaccherini said: "They faced Shakhtar Donetsk on Wednesday. Ukraine is a long way to travel and that can affect your performance in the next game.
"I saw this at Juventus. It was never easy when we played Champions League football in the week and then three days later had a league game.
"United have not started as well as they wanted and if we can pick up a result it will give everyone such a lift."
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