In arguably one of the most dramatic Premier League title deciders ever, an Aguero goal deep into injury time against Queens Park rangers helped City snatch the title away from rivals Manchester United back in May of 2012.
Inter Milan's Mancini was the manager of City at the time and more than three years on from the euphoric scenes at the Etihad Stadium, the Italian has stated that Aguero's dramatic goal still resonates strongly with him.
"We went behind against QPR before they went down to 10 men at a certain point," Mancini told Sky Sport Italia.
"It was both fortunate and unfortunate because they then put all of their men behind the ball, which never happens in England.
"We scored the goal to make it 2-2 in the 92nd minute thanks to a [Edin] Dzeko header, with the referee having put only four minutes of added time on the clock. When play recommenced, the QPR manager told his players that the other game had finished and that they were safe, and so instead of knocking the ball around they simply kicked a long ball forward.
"It was the 92nd minute, and I still shudder when telling the story. I prayed to the Virgin Mary and said: 'You cannot possibly abandon me now'.
"The ball fell to [Mario] Balotelli, because he is always there at the end, and whilst being fouled he was able to give a ball on-the-slide to Aguero, who at 93 minutes and 30 seconds scored the decisive goal.
"We were strong enough to play until the last second and it still brings me a great thrill to think of it."