The Red Devils were seemingly in control after Dimitar Berbatov had scored with a header from a Ryan Giggs corner in the 42nd minute before adding a second with a genius overhead kick just prior to the hour-mark.
But Liverpool hit back through inspirational skipper Steven Gerrard who converted from the penalty spot five minutes later before tying up the clash in the 70th minute with a neat finish from a free-kick.
Not be to be outdone, Berbatov grabbed his hat-trick and maximum points for United by scoring the winner six minutes from time in an exciting finish.
MU Edwin van der Sar (gk), Jonathan Evans, Nemanja Vidic, Patrice Evra, John O'Shea, Darren Fletcher, Paul Scholes, Ryan Giggs (Macheda 82'), Nani (Gibson 88'), Wayne Rooney, Dimitar Berbatov (Anderson 88')
LIV Pepe Reina (gk), Martin Skrtel, Jamie Carragher, Paul Konchesky (Agger 82'), Glen Johnson, Christian Poulsen, Steven Gerrard, Fernando Torres, Raul Meireles (Jovanovic 79'), Joe Cole, Maxi Rodriguez (Ngog 62')