United remain seven clear of Manchester City and without some kind of injury affecting Robin van Persie, it is difficult to see the Red Devils squandering their advantage in the same way they did 12 months ago.
Ferguson is taking every precaution, and that means resting key men for next week's FA Cup tie at West Ham United.
"We will make a few changes for the cup tie," said Ferguson.
"We took Michael Carrick off as soon as we got the third goal. They deserve a break and they have played in all the games.
"We'll have a look at the situation. We've got plenty of players to freshen it up."