The Red Devils take on German club FC Schalke in the Champions League semi-final second leg at Old Trafford on Wednesday night and the Scottish tactician admits that the team which lost 1-0 to Arsenal yesterday will be altered to protect some of his stars.
"I will make some changes on Wednesday without question," said Ferguson.
"We'll need to do that but I will probably keep my experienced players at the back.
"We have a big week ahead. Wednesday is a European semi-final second leg and then the game on Sunday (against Chelsea which could define the league title).
"Two massive games, so we will regroup and freshen it up."