A number of United players will be involved in the England versus Wales match at Wembley tomorrow night, with Wayne Rooney, Ashley Young and Chris Smalling likely to see action whilst Patrice Evra will be on duty with France (against Romania), Darren Fletcher for Scotland (against Lithuania) and Anders Lindegaard for Denmark (against Norway).
Ferguson is used to having internationals on duty away from United but just hopes there are no injuries ahead of the weekend's clash at Bolton.
"You've just got to accept it," he told MUTV. "There's nothing you can do about it.
"Over the last year, we had Paul [Scholes], Gary [Neville], Ryan [Giggs] and Edwin [van der Sar] who had retired from internationals so we had the benefit of having those players for weekends.
"Now those players, bar Giggsy, are away from us so most of the players are going to internationals.
"We have to keep our fingers crossed that they come back healthy. Sometimes we're lucky, sometimes we're not. It's not in our hands.
"The only benefit is the internationals are now Tuesday fixtures and that gives us an extra day to prepare for weekend games."