Fergie has warned Roberto Mancini there will be no slip-ups from his team this year.
Manchester United blew an eight-point lead with six games to go last season as neighbours City claimed the title.
Now United could have a 10-point cushion if they beat Fulham today.
Ferguson said: "I don't expect my players to become complacent. This season we should take care of it because we have the experience to take care of it."