The replay of the 2009 FA Cup final ended with Everton and Chelsea sharing the spoils in a 1-1 draw at Goodison Park, whilst Birmingham came from two goals down to defeat English Championship opposition. The Blues will be relieved with the draw as Everton dominated the second half but failed to take their chances and boss David Moyes will surely think this failure to win at home was their best chance to progress.
The Toffees deservedly took the lead just after the hour when Louis Saha lost his marker John Terry at a corner to bury a header.
But Everton failed to capitalise and substitute Salomon Kalou on a lightening visitor's breakaway coolly netted the equaliser with 15 minutes remaining.
These two teams have now met in the Carling Cup and FA Cup, this season and last season, and in all encounters Villa have triumphed.
All the goals in today's clash came in the first half as both managers fielded inexperienced teams in what turned out to be a lively encounter.
Ciaran Clark nodded the host's ahead early on but Rovers were level within seven minutes as Nikola Kalinic bundled home from close range.
But two goals close to half time settled the tie. Robert Pires scored his first goal for Villa to put them back in front and Nathan Delfouneso took advantage of slack Blackburn marking to head number three.
Defender Nathan Baker saw a straight red for a wild tackle on David Hoilett but Gerard Houllier's team finished the game comfortably protecting their two goal advantage.
Carling Cup finalists Birmingham looked to on the way out of the FA Cup when they found themselves two goals down within the first 26 minutes at St Andrews to midlands rivals Coventry.
But a goal just before the break and a second half revival saw them defeat their Championship opponents.
The Sky Blues, who had lost their previous three away games, capitalised on some poor home defending to take a 2-0 lead through Marlon King's 18-yard drive and Richard Wood's header from a corner.
On loan David Bentley from Tottenham then reduced the deficit before the break.
Stuart Parnaby fired in the equaliser followed quickly by veteran Kevin Phillips winner which should boost morale for the Blues fight against relegation.
Both league meetings between Bolton and Wigan have ended in dour draws and even though they again shared the spoils in a scoreless draw at the Reebok Stadium, this was a more entertaining encounter.
Bolton's Johan Elmander fired over early in the match, while Martin Petrov went close with a low drive.
And late on, Bolton debutant David Wheater shot just wide as either side could have produced a winner in the closing stages.