League One Notts County stunned Sunderland with a 2-1 win and Southampton and Reading disposed of Blackpool and West Bromwich Albion respectively. Arsenal almost made all the wrong headlines with their early kick-off against Leeds.
Trailing one-nil to the Championship side following a second half penalty, they needed a last minute spot kick of their own to take the game to a replay at Elland Road.
Blackburn ensured there were no shocks at Ewood Park against Championship leaders QPR.
Both teams played weakened side's which made for a poor game.
The visitor's did hit the woodwork but the only goal of the game came with 13 minutes remaining as Rovers Canadian David Hoilett calmly slotted the winner.
Bolton defeated non-league York 2-0 at the Reebok but were given a fright by the Blue Square Bet Premier league outfit.
The Wanderers needed two goals in the last seven minutes to clinch the win and prevent an embarrassing replay.
Kevin Davies and Johan Elmander saved the Trotters blushes with 98 league places separating the two teams.
Ten man Wolves will be pleased to have escaped with a 2-2 draw at Doncaster.
The visitor's took the lead through Nenan Milijas but Donny quickly levelled from Billy Sharp.
The Championship team then took the lead almost immediately with Jamie Hayter just before the break.
Wolves equalised through a Stephen Hunt penalty then had to survive the last 13 minutes with ten men as George Elokobi was sent off for a reckless challenge.
There were no upsets at Craven Cottage as Diomansy Kamara scored a hat-trick for Fulham in the 6-2 demolition of League One Peterborough.
Dickson Etuhu, Zoltan Gera and Jonathan Greening also got on the score-sheet for the Cottagers, with Lee Tomlin and Grant McCann from the penalty spot, replying for the visitor's to give their 5,000 travelling support some consolation.
Wigan went to Hull and came away with a 3-2 win despite a spirited fightback from the Tigers.
Mohamed Diame scored a brace for the Latics, either side of a Callum McManaman effort, as they twice led by two goals only for Hull to respond with Nick Barmby scoring twice to set up a tense finish, but it was too little too late for the home side.
Birmingham easily moved into the next round with some clinical finishing in a 4-1 win at Millwall which slightly flattered the victors who had been second best for most of the first half.
A goal just before half-time by Shane Long was enough for Reading to see of Premiership West Brom 1-0 as the Baggies woeful run of form continues.
Albion also had Jonas Olsson dismissed for two rapid yellow cards and rarely threatened although James Morrison headed a good chance wide.
Everton made short work of Championship strugglers Scunthorpe easing to a 5-1 away win.
Marc Albrighton had made it 2-0 by the break.
Cardiff earned a home replay against Stoke after drawing 1-1 at the Britannia Stadium.
West Ham put their relegation worried to one side and eased past Barnsley 2-0 at Upton Park with goals from Jonathan Spector and Frederic Piquoinne, the latter's coming deep into added time at the end of the game.